
胡美变,女,1992年4月出生,毕业于成都中医药大学。博士,副教授,山西中医药大学硕士生导师。先后主持国家自然科学基金、山西省科技厅等科研项目6项,发表论文50余篇,其中SCI论文30篇。
研究学科(领域):中药炮制学
研究方向:中药炮制现代研究;中药炮制原理与蛋白类成分
科研项目:
1. 基于“蛋白质/肽组学-修饰组学”的僵蚕“粉末饮片”的炮制原理研究(82104397),国家自然科学基金委员会青年基金项目,2022.01-2024.12,30万元,主持
2. 炒僵蚕粉末入药“息风止痉”的物质基础及作用机制研究(20210302124630),山西省科技厅基础研究计划青年项目,2022.01-2024.12,4万元,主持
3. “杏林英才计划”科技创新领域人才(2025XK13),山西中医药大学,2025.08 -2028.07,30万元,主持
4. 基于多糖转化和CREB/TrkB/BNDF信号通路的制远志“长于益智”炮制机理研究(2024ZYY2C098),山西省中医药管理局中医药科研课题,2024.11-2027.11,2万元,主持
5. 基于“蛋白质/肽组学”的僵蚕麸炒炮制科学内涵研究(2022BK07),山西中医药大学博士科研启动基金项目,2022.07-2025.06,8万元,主持
6. 麸炒僵蚕炮制前后肽类成分分析及神经保护作用研究(2022BKS04),山西中医药大学优秀博士毕业生来晋工作奖励经费科研启动基金项目,2022.07- 2024.06,5万元,主持
代表性成果:
1. Jing-ya Wang, Xi Peng, Qiao-Ling Deng , Zhi-Kun Wang , Kui-Xu Gao , Yao Wang , Yu-jie Liu*, Mei-bian Hu*. Proteins derived from Bombyx batryticatus utilizing variable ultrasound powers: Evaluation of structural attributes, functional characteristics, and antioxidant capacities. Ultrasonics Sonochemistry, 2025; 119: 107394.(中科院1区,IF=9.7)
2. Peng Xi, Wang Jing-Ya, Gao Kui-Xu, Wang Zhi-Kun, Deng Qiao-Ling, Wang Yao, Hu Mei-Bian*, Liu Yu-Jie*. Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities. Ultrasonics Sonochemistry, 2025: 113: 107243.(中科院1区,IF=9.7)
3. Yu-Jie Liu, Kui-Xu Gao, Xi Peng, Yao Wang, Jing-Ya Wang, Mei-Bian Hu*. The great potential of polysaccharides from natural resources in the treatment of asthma: A review. International Journal of Biological Macromolecules, 2024, 260 (Pt1): 129431.(中科院2区Top,IF=8.5)
4. Gao Kuixu, Peng Xi, Wang JingYa, Wang Yao, Pei Ke, Meng XiangLong, Zhang ShuoSheng, Hu MeiBian*, Liu YuJie*. In vivo absorption, in vitro simulated digestion and fecal fermentation properties of polysaccharides from Pinelliae Rhizoma Praeparatum Cum Alumine and their effects on human gut microbiota. International Journal of Biological Macromolecules, 2024;266(Pt 2):131391.(中科院2区Top,IF=8.5)
5. Hu Mei-Bian, Gao Kui-Xu, Wang Yao, Liu Yu-Jie*. Characterization of Polysaccharides from the Pericarp of Zanthoxylum bungeanum Maxim by Saccharide Mapping and Their Neuroprotective Effects. Molecules, 2023, 28: 1813.(中科院3区,IF=4.6)
6. Liu Yujie, Meng Xianglong, Sun Lin, Pei Ke, Chen Lin, Zhang Shuosheng*, Hu Meibian*. Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl3-induced Alzheimer’s disease-like mice via Nrf2/HO-1 signaling pathways. European Journal of Pharmacology, 2022, 914: 174691.(中科院2区,IF=5.0)
7. Hu Mei-Bian, Meng Xiang-Long, Wang Pu, Zhang Shuo-Sheng, Wu Chun-Jie, Liu Yu-Jie. Purification, Identification and Neuroprotective Effects of Proteins from Bombyx batryticatus in Glu-Stimulated PC12 Cells. Separations, 2022, 9, 236.(中科院3区,IF=2.7)
8. He Liying#, Hu Meibian#, Li Ruolan, Zhao Rong, Fan Linhong, He Lin, Lu Feng, Ye Xun, Huang Yongliang*, Wu Chunjie*, Natural Medicines for the Treatment of Epilepsy: Bioactive Components, Pharmacology and Mechanism, Frontiers in Pharmacology, 2021, 12: 604040.(中科院2区,IF=5.988)
9. 王瑶, 高奎旭, 王静雅, 彭溪, 王治焜, 邓巧玲, 张朔生, 刘玉杰, 胡美变*. 基于糖谱法的僵蚕多糖结构特征分析及抗氧化活性研究 [J]. 中国医院药学杂志, 2024, 44 (16): 1882-1889.
10. 胡美变, 高奎旭, 王瑶, 彭溪, 王静雅, 孟祥龙, 张朔生, 黎江华, 刘玉杰*. 基于糖谱法的半夏及其炮制品多糖结构特征分析及水/酶解前后抗氧化活性评价 [J]. 中国实验方剂学杂志, 2024, 30 (11): 192-201.
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