李秀英，女，1984年8月出生，毕业于北京大学。博士，副教授，山西中医药大学硕士生导师，中药药剂学科方向带头人。先后主持国家自然科学基金及省部级科研项目6项，发表论文38篇，其中中文核心（或SCI）论文30篇，参编教材及著作6部。
研究学科（领域）：中药药剂学、中药制剂技术研究与质量评价
研究方向：中药新制剂与智能药物递送系统研究
科研项目：
1.基于微环境逐级响应的中药尺寸收缩型复合载体抗类风湿性关节炎增效减毒作用与机制研究（202303021211171），山西省应用基础研究项目，2024.01- 2026.12, 10万元，主持；
2.小檗碱黄芩苷多功能靶向胶束治疗类风湿性关节炎协同增效作用研究（2022ZYYC087），山西省中医药管理局科研项目，2022.11.10 -2025.11.09，1万元，主持；
3.基于精准调控巨噬细胞策略的强渗透性雷公藤甲素脂质复合体抑制RA骨损伤研究（2024PY-NS-009），山西中医药大学科技创新能力培育计划国自然培育专项，2024.07-2026.06，5万元，主持；
4.基于尺寸收缩型级联靶向胶束的中药抑制乳腺癌转移效应及机制研究（81903813），国家自然科学基金青年基金项目，2020.01-2022.12，21万元，主持；
5.基于肿瘤生物屏障的微环境多刺激响应型智能紫杉醇脂质胶束的研究（201801D221434），山西省应用基础研究项目，2018.12-2020.12，3万元，主持。
代表性成果：
1.Yang Yu, Liang Kong, Rui-bo Guo, Ya-ni Zhang, Shu-tong Li, Feng-yuan Zhang, Xin Wang, Yang Liu, Xiu-Ying Li* and Xue-tao Li*. Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway. Journal of Nanobiotechnology, 2025 (23):509.
2. Ruibo Guo, Liang Kong, Yang Yu, Yang Liu, Lu Zhang, Xiuwu Qu, Shutong Li, Junjie Yu, Xuetao Li*, Xiuying Li*. Matrix metalloproteinase-sensitive size-shrinkable liposomes targeting activated macrophages for the treatment of rheumatoid arthritis. Applied Materials Today, 2024(38):102182.
3. Xiuying Li, Xin Wang, Xiuwu Qu, Ningning Shi, Qinqing Li, Zhifang Yan, Yandong Li*, Yingli Wang*. Microenvironmental enzyme-responsive methotrexate modified Quercetin micelles for the treatment of rheumatoid arthritis. International Journal of Nanomedicine 2024(19): 3259-3273.
4. Jiaqi Si, Ruibo Guo, Lu Zhang, Wanying Liu, Liang Kong, Yang Liu, Yang Yu, Juan Zang, Weiwei Chen, Xiuying Li*, Xue-tao Li*. Mannose-modified celastrol liposome targeted therapy for rheumatoid arthritis in vivo and in vitro evaluation. Journal of Drug Delivery Science and Technology.2024(91):105185.
5. Yang Yu, Siyu He, Liang Kong, Ningning Shi, Yang Liu, Juan Zang, Ruibo Guo, Lu Zhang, Xiuying Li*, Xuetao Li*, Brain-targeted multifunctional micelles delivering Oridonin and Phillyrin for synergistic therapy of Alzheimer's disease. Journal of Drug Delivery Science and Technology. 2023(87):104794.
6. Muhan Chen, Xinze Liu, Xiuwu Qu, Ruibo Guo, Lu Zhang, Liang Kong, Yang Yu, Yang Liu, Juan Zang, Xiuying Li*, Xuetao Li*. ApoE-modified resveratrol plus salidroside liposomes cross blood-brain barrier and alleviate Alzheimer's disease in APP/PS-1 mice. Drug Development & Industrial Pharmacy. 2023,49(9): 559-571.
7. Xiuying Li*#, Luanxia Shi#, Ningning Shi, Weiwei Chen, Xiuwu Qu, Qinqing Li, Xiujun Duan, Xuetao Li*, Qingshan Li*. Multiple stimulus-response berberine plus baicalin micelles with particle size-charge-release triple variable properties for breast cancer therapy. Drug Development & Industrial Pharmacy. 2023,49(2):189-206.
9. Xiuying Li, Luanxia Shi, Xuemin Yao, Ming Jing, Qinqing Li, Yingli Wang*, Qingshan Li*. Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of Gastric cancer. Drug Development & Industrial Pharmacy. 2021, 47(1):100-112.
10. Xiuying Li, Jianhua Wang, Liyan Gu, Xuemin Yao, Fuyi Cai, Ming Jing, Xuetao Li*, Ruijun Ju*. Dual variable of drug loaded micelles in both particle and electrical charge on gastric cancer treatment, Journal of Drug Targeting, 2020,28(10):1071-1084.
11. Xiuying Li, Luanxia Shi, Yandong Li, Qinqing Li, Xiujun Duan, Yingli Wang*, Qingshan Li*. The enhanced treatment efficacy of invasive brain glioma by dual-targeted artemether plus paclitaxel micelles. Artificial Cells, Nanomedicine, and Biotechnology. 2020,48(1):983-996.
12. Xiu-Ying Li，Yao Zhao，Meng-Ge Sun，Ji-Feng Shi，Rui-Jun Ju，Cheng-Xiang Zhang，Xue-Tao Li，Wei-Yu Zhao，Li-Min Mu，Fan Zeng，Jin-Ning Lou，Wan-Liang Lu. Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma，Biomaterials，2014，35（21）：5591-5604.
联系方式：
办公电话：15525016106
Email：lixiuying@sxtcm.edu.cn
